辉瑞制药有限公司James J. Mousseau等报道通过高通量反应条件优化,发展了条件温和的光催化Minisci型反应,构建高度官能团化修饰的1,3-双位点修饰双环戊烷。
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参考文献
James J. Mousseau,* Matthew A. Perry, Mark W. Bundesmann, Gary M. Chinigo, Chulho Choi, Gary Gallego, Robert W. Hicklin, Susan Hoy, David C. Limburg, Neal W. Sach, and Yuan Zhang, Automated Nanomole-Scale Reaction Screening toward Benzoate Bioisosteres: A Photocatalyzed Approach to Highly Elaborated Bicyclo[1.1.1]Pentanes, ACS Catal. 2022, 12, 600-606
DOI: 10.1021/acscatal.1c05076
https://pubs.acs.org/doi/10.1021/acscatal.1c05076